Understanding users’ trust transfer mechanism in food delivery APP

With the rapid dissemination of mobile technologies, along with hectic life nowadays, consumers are more in favor of food delivery apps (FDA). However, many aspects related to the usage of FDAs have not been fully unearthed. Drawing upon the trust transfer theory, the study theorizes the consumer’s trust formation in FDA and investigates the antecedents of trust to platform and trust to a merchant that mediates the continuous usage intention and purchase intention. The proposed framework was tested through structural equation modeling (SEM) based on an online questionnaire. The findings illustrate the trust transfer mechanism in the context of the FDA and its effects, which have both theoretical and practical implications for different stakeholders

Megastigmans and other compounds from Antidesma hainanensis Merr.

Four megastigmans 7-megastigmene-3-ol-9-one 3-O-[α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside]  (1),  alangionoside L (2),  alangioside (3), ampelopsisionoside (4), and other constituents as N–trans-feruloyloctopamide (5), trans-linalool-3,6-oxide-β-D-glucopyranoside (6),  5α,8α-dipioxiergosta-6,22-diene-3β-ol (7), and (Z)-2-hexenyl β-D-glucopyranoside (8) were isolated from the methanol extract of the Antidesma hainanensis leaves. Their chemical structures were successfully determined using NMR and ESI-MS analysis as well as in comparison with the reported data. This is the first report of these compounds from Euphorbiaceae family

Anticaries activity of mangiferin isolated from Mangifera indica leaves in Vietnam

Mangiferin (1) was isolated from Vietnamese Mangifera indica leaves. Its antimicrobial activities against the oral bacterium Streptococcus mutans GS-5 were evaluated in terms of inhibition of acid production and biofilm formation. The obtained results indicated that mangiferin at the concentration of 0.5 mM clearly inhibited acid production by this organism with a final pH value of 5.2 compared to 3.9 of the control. The reduction in biofilm biomass was found up to 92 % when it was treated with 1.0 mM mangiferin. Thus, mangiferin possesses moderate anticaries activity against S. mutans GS-5. Keywords. Mangifera indica, mangiferin, Streptococcus mutans, anticaries activity

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Achyranbidens A–C: three new compounds from <i>Achyranthes bidentata</i> Blume

Phytochemical study on the roots of Achyranthes bidentata Blume led to the isolation of sixteen compounds including three new ones (1–3). Their chemical structures were determined as oleanolic acid 28-O-β-D-glucopyranoside-3-O-[β-D-glucopyranosyl-(1→3)-β-D-galactopyranoside) (1), methyl (8Z,11Z)-5,6,7-trihydroxytetradeca-8,11-dienoate (2), methyl (6E,11Z)-5,8,9-trihydroxytetradeca-6,11-dienoate (3), fulgidic acid (4), (9E,11E)-13-oxooctadeca-9,11-dienoic acid (5), (9Z,11E,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid (6), oleanolic acid 28-O-β-D-glucopyranoside-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucuronopyranoside (7), oleanolic acid 28-O-β-D-glucopyranoside-3-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucuronopyranoside (8), oleanolic acid 3-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucuronopyranoside (9), oleanolic acid 3-O-α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranoside (10), blumenol C glucoside (11), citroside A (12), 6S,9S-roseoside (13), ginsenoside Rg1 (14), 20-hydroxyecdysone (15), and benzyl α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (16) by spectroscopic analysis. Compounds 1, 7 and 11–16 inhibited NO production in LPS-activated RAW264.7 cells with IC50 values in the range from 28.03 to 54.23 µM (positive control, L-NMMA: IC50 = 35.52 µM). Compounds 14 and 15 showed anti α-glucosidase activity with IC50 values of 176.24 and 156.92 µM, respectively, compared with the positive control, acarbose, IC50 = 160.99 μM.</p

Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis

Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC50 = 9.9 μM). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 μM for each compound). Compound 1 was inactivity in both cytotoxic and antimicrobial assays.Fil: Luyen, Nguyen Dinh. Vietnam Academy of Science and Technology; Vietnam. Graduate University of Science and Technology; VietnamFil: Huong, Le Mai. Vietnam Academy of Science and Technology; Vietnam. Graduate University of Science and Technology; VietnamFil: Thi Hong Ha, Tran. Vietnam Academy of Science and Technology; VietnamFil: Cuong, Le Huu. Vietnam Academy of Science and Technology; VietnamFil: Thi Hai Yen, Duong. Institute of Marine Biochemistry; VietnamFil: Nhiem, Nguyen Xuan. Graduate University of Science and Technology; Vietnam. Institute of Marine Biochemistry; VietnamFil: Tai, Bui Huu. Graduate University of Science and Technology; Vietnam. Institute of Marine Biochemistry; VietnamFil: Gardes, Astrid. Leibniz Centre for Tropical Marine Research; AlemaniaFil: Kopprio, Germán Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Leibniz Centre for Tropical Marine Research; AlemaniaFil: Van Kiem, Phan. Graduate University of Science and Technology; Vietnam. Institute of Marine Biochemistry; Vietna

Gold Nanoparticles Modified a Multimode Clad-Free Fiber for Ultrasensitive Detection of Bovine Serum Albumin

Gold nanoparticles (Au NPs) were almost chosen as the first option for biological and biosensor applications due to their enhancement and their outstanding properties. The combining of optical fiber with localized surface plasmon resonance (LSPR) for forming a biosensor is widely used in diagnosis. In this work, we report a fiber optical biosensor based on LSPR of Au NPs for the detection of bovine serum albumin (BSA) protein. BSA was functionalized on Au NPs immobilized fiber optic sensing head (length of 1 cm) via methanesulfonic acid (MSA) by carboxylic binding. It is the binding between the analytes with the surface-modified Au NPs that caused refractive index changes in the sensing medium led to changes in optical power at the output of the sensor. The detection limit of the LSPR fiber biosensor was found to be 0.18 ng/mL for the BSA detection with the low coefficient of variation (CV) at under 1%. We have demonstrated the effectiveness of combining multimode fiber with Au NPs to generate the biosensor as the label-free sensor that can be a feasible tool for highly sensitive, rapid response time, stable, and miniaturized point-of-care analytical systems

Annotated photos of the “arm-in-cage” method.

<p><b>(A)</b> Mosquito repellent (2 mL) was applied onto all sides of a single forearm, between the elbow and wrist (repellent-treated arm). The opposite limb had no repellent applied, and was used as an internal control (repellent free arm). <b>(B)</b> The participant inserted her/his arms into the two mosquito cages simultaneously. Each cage contained ten <i>Aedes aegypti</i> mosquitoes. <b>(C)</b> A mosquito (circled) landing on a participant’s arm during an exposure. The arms were exposed for a maximum of 2 minutes each time. “Landing for 2 seconds” was used as a proxy for mosquito biting. After a mosquito landed on a participant, they were asked to shake off the mosquito and withdraw their arm from the cage. Alternatively, the participant withdrew their arms only at the end of the two-minute exposure if there was no mosquito landing, and the exposure was repeated at the next scheduled interval.</p

Survey responses of (A) physicians and (B) patients on general knowledge of DENV tranmission and prevention.

<p>Black bars represent the proportion of responses given by participants, who agreed with the statement. The light-grey part of each bar represents the proportion of participants, who did not agreed with the statement. The dark grey bars show the proportion of participants who reported that they did not know the response to that question.</p

Demographic characteristics of participants in the patient group who responded to the KAP survey.

<p>Demographic characteristics of participants in the patient group who responded to the KAP survey.</p